Update on therapeutic options in Waldenström macroglobulinemia
نویسندگان
چکیده
منابع مشابه
Update on therapeutic options in Waldenström macroglobulinemia.
Waldenström macroglobulinemia (WM) is a B-cell disorder characterized primarily by bone marrow infiltration with lymphoplasmacytic cells (LPCs), along with demonstration of an IgM monoclonal gammopathy in the blood. WM remains incurable, with 5-6 yr median overall survival for patients with symptomatic WM. The main therapeutic options include alkylating agents, nucleoside analogues, and rituxim...
متن کاملWaldenström macroglobulinemia.
Waldenström macroglobulinemia is a lymphoplasmacytic lymphoma. A serum monoclonal IgM protein is required to establish this diagnosis. The clinical features patients develop include normochromic normocytic anemia, thrombocytopenia, hepatosplenomegaly, lymphadenopathy and signs of hyperviscosity. The International Staging System for Waldenström macroglobulinemia divides patients prognostically ...
متن کاملExtramedullary Waldenström macroglobulinemia.
Disease assessment in Waldenstrom Macroglobulinemia (WM) is dependent on the percent involvement of B-cell neoplasm in the bone marrow and IgM paraprotein in the serum. A subset of patients also demonstrates extramedullary involvement, which is infrequently examined. The role of extramedullary involvement in the diagnosis and prognosis of WM is poorly understood. The purpose of this study is to...
متن کاملRisk of second cancers in Waldenström macroglobulinemia.
BACKGROUND An increased incidence of second cancers has been reported in lymphoproliferative disorders. PATIENTS AND METHODS We assessed the frequency, characteristics and predictive factors of second cancers in 230 patients with Waldenström macroglobulinemia (WM) and compared the incidence of second cancers in WM with that of an age- and sex-matched control population. RESULTS Twenty-two p...
متن کاملDiagnostic challenges of amyloidosis in Waldenström macroglobulinemia.
Amyloidosis associated with immunoglobulin M clones is a distinct clinical entity that poses specific challenges to clinicians. Although there is substantial overlap, the pattern of organ involvement is peculiar, with higher frequencies of lung, lymph nodes, and peripheral nervous system involvement. Early diagnosis is vital to start effective therapy before irreversible organ damage has occurr...
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ژورنال
عنوان ژورنال: European Journal of Haematology
سال: 2009
ISSN: 0902-4441,1600-0609
DOI: 10.1111/j.1600-0609.2008.01171.x